Abstract: The aim of the paper is to analyse the role of Clement Colson in the development of economic calculus in France. First of all this study demonstrates that he is one of the few French liberal economists of the early 20th century to use mathematics. Then this article shows that he is one of the pioneers of the use of statistics in economics. Finally, his simultaneous use of statistics and mathematics allows to consider him as an author facilitating the first project of econometrics diffusion in France.