Abstract: Giordano Bruno in The Cause, principle and One develops an ontological alternative to the Aristotelian-Scholastic tradition, by rehabilitating the pre-Socratic and medieval philosophies that it had criticized. He thus develops a philosophy of nature that integrates the two perspectives, physical and metaphysical, by reformulating the relationship between their objects, nature and being, the deep link between unity and multiplicity and the order of sciences, natural and speculative.