Abstract: Through the demolition of Aristotelian metaphysics and the reinterpretation of Epicureanism, Vanini constructs a materialist intuition of the universe, based on the autonomy of reason and nature. The machina mundi, of a mechanistic nature, is not moved by any external principle: matter is active and eternal. Against the principle of the fixity of species, Vanini affirms that the animal instinct and human reason are in continuity and that even the Aristotelian forms (the rational soul included in the human seed) are mixed.